"MENDS-on-FHIR: Leveraging the OMOP Common Data Model and FHIR Standards for National Chronic Disease Surveillance," published in JAMIA Open (Volume 7, Issue 2, July 2024 online May 29, 2024) found that using the Bulk FHIR® data standard could increase interoperability and reduce barriers to accessing data for public health surveillance. The study presents a technical approach for enhancing interoperable data exchange in chronic disease surveillance efforts. Read more here

Health Data Compass proudly announces its attainment of the esteemed ISO 27001 Certification, solidifying its position as a leader in information security and data protection. Read the full story here.

The university noted in its news release the researchers will work with UCHealth’s Health Data Compass, School of Medicine IT, and guidance from Colorado Multiple Institutional Review Board, along with regulatory, compliance, and informatics leaders on campus.

Kalpathy-Cramer and her team have a lot of data to pull from at the eye center for the research including data from UCHealth's Health Data Compass.

Dr. Michael Rosenberg, a cardiac electrophysiologist at CU, and his colleagues have examined deep-learning models that use electronic records from the Health Data Compass warehouse to predict those at greatest risk of developing a life-threatening heart rhythm disorder called QT prolongation after taking one of more than 100 medications.

Recognizing the growing importance of data governance, Health Data Compass is one company that is improving efficiencies and delivering more value to researchers by adopting cloud-based infrastructure and automation to drive impactful research analytics.

As cloud computing becomes the norm, organizations like ours, Health Data Compass at the Colorado Center for Personalized Medicine, continue to partner with innovative organizations to advance our mission of supporting research analytics.

MENDS (Multi-state EHR-based Network for Disease Surveillance) is adding a FHIR Bulk Data service and will provision the data warehouse via a FHIR Bulk Data client

With extensive analytical tools and a 6M patient record research data warehouse on Google Cloud platform, the Colorado Center for Personalized Medicine delivers “no-barriers” data and analytics under unforeseen scenarios like the COVID-19 pandemic.

Google Cloud Platform securely powers the Health Data Compass data warehouse of patient records and genetic data to personalize disease diagnosis and treatment, and to develop new therapies.

Health Data Compass presents at the Google Cloud Next conference on HIPPA compliance in Cloud technology and its implications for users.

The Colorado Center for Personalized Medicine (CCPM), a partnership among the University of Colorado Denver, UCHealth, Children's Hospital Colorado, and CU Medicine, is using Tableau Software (NYSE: DATA), a global leader in visual analytics, and Google Cloud Platform (GCP) to analyze patient data to predict disease risk and develop targeted treatments based on an individual's health history in support of breakthrough research projects. 

Health Data Compass, an analytics initiative supported by four major healthcare provider organizations in the Denver area, is leveraging cloud-based data management to integrate patient genomic data and EHR data to drive forward personalized medicine.

University of Colorado Denver executives say the switch has given new legs to the analytics push, called Health Data Compass, which is part of the Colorado Center for Personalized Medicine. 

University of Colorado Health (UC Health) takes its mission to “push the boundaries of medicine” very seriously. 

2024 Journal Articles

Validation of Multi-State EHR-Based Network for Disease Surveillance (MENDS) Data and Implications for Improving Data Quality and Representativeness

A polygenic risk score for the QT interval is an independent predictor of drug-induced QT prolongation

Validation of Multi-State EHR-Based Network for Disease Surveillance (MENDS) Data and Implications for Improving Data Quality and Representativeness

Acute Care Rehabilitation Services Utilization and Post-acute Discharge Destination among Adults with Traumatic Brain Injury: The Moderating Effect of Functional and Physical Performance at Discharge

Weight change with antiretroviral switch from integrase inhibitor or tenofovir alafenamide-based to Doravirine-Based regimens in people with HIV

Validation of the Safety and Efficacy of Apixaban as Postoperative Thromboembolism Prophylaxis for Patients with Gynecologic Malignancies

Cost-effectiveness analysis of CYP3A5 genotype-guided tacrolimus dosing in solid organ transplantation using real-world data

Association between continuous glucose monitoring metrics and clinical outcomes in adults with type 1 diabetes in a real-world setting

Shifting patterns of multiple sclerosis treatment in a highly prevalent United States population

A Single-center Case Series of Patients with Stiff-person Syndrome (P1-14.001)

Epidemiology of Seropositive Neuromyelitis Optica Spectrum Disorder in a Large US Population (P10-14.013)

A Stochastic Model-Based Control Methodology for Glycemic Management in the Intensive Care Unit

Risk of COVID‐19 Hospitalization and Protection Associated With mRNA Vaccination Among US Adults With Psychiatric Disorders

Real-world use of nirmatrelvir-ritonavir in COVID-19 outpatients during BQ.1, BQ.1.1., and XBB.1.5 predominant omicron variants in three U.S. health systems: a retrospective cohort study

Effect of prednisone dosing on mineralocorticoid-related side effects with abiraterone in prostate cancer.

Safety and efficacy of insulins in critically ill patients receiving continuous enteral nutrition

Fostering Governance and Information Partnerships for Chronic Disease Surveillance: The Multi-State EHR-Based Network for Disease Surveillance

Building a vertically integrated genomic learning health system: The biobank at the Colorado Center for Personalized Medicine

Five functional classes identified among patients hospitalized for pneumonia characterized by activity limitations with mobility and self-care tasks

Using electronic health records to enhance surveillance of diabetes in children, adolescents and young adults: a study protocol for the DiCAYA Network

2023 Journal Articles

Cardiovascular Events Before and After Initiation of Immune Checkpoint Inhibitor Therapy for Cancer

A methodology of phenotyping ICU patients from EHR data: High-fidelity, personalized, and interpretable phenotypes estimation 

Recovery From Idiopathic Sudden Sensorineural Hearing Loss: Association With Cardiovascular Disease Risk 

Sudden Shift to Telehealth in COVID-19: A Retrospective Cohort Study of Disparities in Use of Telehealth for Prenatal Care in a Large Midwifery Service 

Development of a novel cancer survivorship database to describe health care utilization patterns for Coloradans who have completed primary cancer treatment 

Sickle Cell Trait Is Associated with Adverse Clinical Outcomes in a Matched Case-Control Study at a Tertiary Care Center 

MENDS-on-FHIR: Leveraging the OMOP common data model and FHIR standards for national chronic disease surveillance 

Reducing the receipt of contraindicated medications in patients with Parkinson disease 

A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy 

Effectiveness of COVID-19 vaccines at preventing emergency department or urgent care encounters and hospitalizations among immunocompromised adults: An observational study of real-world data across 10 US states from August-December 2021 

Prescribing Patterns of Dupilumab for Atopic Dermatitis in Adults: Retrospective, Observational Cohort Study 

Prescribing Patterns of Oral Antibiotics and Isotretinoin for Acne in a Colorado Hospital System: Retrospective Cohort Study

Cyclosporine in the Treatment of Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome: Retrospective Cohort Study 

Real-world evaluation of bebtelovimab effectiveness during the period of COVID-19 Omicron variants, including BA.4/BA.5

Real-world use of nirmatrelvir–ritonavir in outpatients with COVID-19 during the era of omicron variants including BA.4 and BA.5 in Colorado, USA: a retrospective cohort study

Metastatic renal cell carcinoma to the pancreas and other sites—a multicenter retrospective study 

Gender disparities in deep brain stimulation surgery for Parkinson disease and essential tremor 

A machine learning evaluation of patient characteristics associated with prescribing of guideline-directed medical therapy for heart failure

Baseline Characteristics of PATHWEIGH: A Stepped-Wedge Cluster Randomized Study for Weight Management in Primary Care

Ontologizing health systems data at scale: making translational discovery a reality

Is Imputation Inevitable or Excessive?

Safety of COVID-19 vaccines in subjects with solid tumor cancers receiving immune checkpoint inhibitors 

Effectiveness of BNT162b2 COVID-19 Vaccination in Children and Adolescents

Patient and Epidemiological Factors Associated With Influenza Testing in Hospitalized Adults With Acute Respiratory Illnesses, 2016–2017 to 2019–2020

Contextualising adverse events of special interest to characterise the baseline incidence rates in 24 million patients with COVID-19 across 26 databases: a multinational retrospective cohort study

Mucosal Ulceration in Gastrointestinal Stromal Tumor is an Independent Predictor of Progression-Free Survival 

Prelude to PATHWEIGH: pragmatic weight management in primary care 

Are Social Determinants of Health Associated With Onset of Rehabilitation Services in Patients Hospitalized for Traumatic Brain Injury? 

Change in effectiveness of sotrovimab for preventing hospitalization and mortality for at-risk COVID-19 outpatients during an Omicron BA.1 and BA.1.1-predominant phase 

Previous corticosteroid exposure associates with an increased Pneumocystis jirovecii pneumonia mortality among HIV-negative patients: a global research network with a follow-up multicenter case-control study 

Characteristics of Emergency Medicine Specimen Bank Participants Compared to the Overall Emergency Department Population

Estimation of COVID-19 mRNA Vaccine Effectiveness and COVID-19 Illness and Severity by Vaccination Status During Omicron BA.4 and BA.5 Sublineage Periods

Leveraging Electronic Health Record Data for Timely Chronic Disease Surveillance: The Multi-State EHR-Based Network for Disease Surveillance 

Differences in cardiac testing resource utilization using two different risk stratification schemes 

Accessing and utilizing clinical and genomic data from an electronic health record data warehouse 

Rare Coding Variants in Patients with Non-Syndromic Vestibular Dysfunction 

Magnitude of troponin elevation in patients with biomarker evidence of myocardial injury: relative frequency and outcomes in a cohort study across a large healthcare system 

Development and validation of models for detection of postoperative infections using structured electronic health records data and machine learning

COVID-19 vaccines in patients with urothelial cancers receiving immune checkpoint inhibitors. 

COVID-19 Mortality in the Colorado Center for Personalized Medicine Biobank 

Relationship of cardiovascular disease risk and hearing loss in a clinical population

Impact of Alcohol Misuse on Requirements for Critical Care Services and Development of Hospital Delirium in Patients With COVID-19 pneumonia

Rehabilitation Therapy Allocation and Changes in Physical Function Among Patients Hospitalized Due to COVID-19: A Retrospective Cohort Analysis

Identification of Disability Subgroups for Patients After Ischemic Stroke 

2022 Journal Articles

Vaccination Trends and Family-Level Characteristics Associated With Incomplete or Delayed Childhood Immunizations: The Healthy Start Study

Delirium Following Anticholinergic Use in Hospitalized Patients With Dementia 

Developing a Collaborative, Team-Based Smoking Cessation Treatment Program in an Outpatient Oncology Setting

External validation of a model to predict future chronic opioid use among hospitalized patients

Chemotherapy delivery in early-onset colorectal cancer is impacted by urban versus rural settings in Colorado

Disparities in the allocation of inpatient physical and occupational therapy services for patients with COVID‐19

Migrating a research data warehouse to a public cloud: challenges and opportunities

Research data warehouse best practices: catalyzing national data sharing through informatics innovation

Unraveling COVID-19: A Large-Scale Characterization of 4.5 Million COVID-19 Cases Using CHARYBDIS

PATHWEIGH, pragmatic weight management in adult patients in primary care in Colorado, USA: study protocol for a stepped wedge cluster randomized trial

Evaluation of Insulin Infusion Rates for the Treatment of Diabetic Ketoacidosis in the Emergency Department

Surgical management and outcomes of endocarditis in adolescents and adults with congenital heart disease

Characteristics and outcomes of COVID-19 patients with COPD from the United States, South Korea, and Europe

Specialized interferon action in COVID-19

COVID-19 Surveillance in the Biobank at the Colorado Center for Personalized Medicine

Identifying Long-Term Morbidities and Health Trajectories After Prolonged Mechanical Ventilation in Children Using State All Payer Claims Data

Predicting Receipt and Types of Occupational Therapy Services for Patients with Arousal Deficits in the Neuro Critical Care Unit

Prospective telehealth analysis of functional performance, frailty, quality of life, and mental health after COVID-19 hospitalization

Evaluation of the Clinical Impact of Thromboprophylaxis in Patients With COVID-19 Following Hospital Discharge

Evaluating for disparities in prenatal genetic counseling

Development and Validation of a Multivariable Prediction Model for Postoperative Intensive Care Unit Stay in a Broad Surgical Population

Real-World Evidence of the Neutralizing Monoclonal Antibody Sotrovimab for Preventing Hospitalization and Mortality in COVID-19 Outpatients

2021 Journal Articles

Comparative effectiveness of direct oral anticoagulants and warfarin for the treatment of left ventricular thrombus.

Etonogestrel contraceptive implant uptake and safety among solid organ transplant recipients.

Prostate Cancer Central Nervous System Metastasis in a Contemporary Cohort.

Characteristics and outcomes of patients with COVID-19 with and without prevalent hypertension: a multinational cohort study.

Characteristics and outcomes of 118,155 COVID-19 individuals with a history of cancer in the United States and Spain.

Improving Postoperative Outcomes in Lower Extremity Amputees Utilizing a Quality Improvement Approach.

Psychiatric comorbidities in functional movement disorders: A retrospective cohort study.

Unraveling COVID-19: a large-scale characterization of 4.5 million COVID-19 cases using CHARYBDIS. 

The Association of Social Factors and Time Spent in the NICU for Mothers of Very Preterm Infants. 

The role of metal patch testing in evaluating patients for metallic prosthetic joint failure.

Characteristics and outcomes of over 300,000 COVID-19 individuals with history of cancer in the United States and Spain.

Acute Myocardial Infarction Cohorts Defined by International Classification of Diseases, Tenth Revision Versus Diagnosis-Related Groups: Analysis of Diagnostic Agreement and Quality Measures in an Integrated Health System. 

SAIGE-BRUSH: an efficient, user-friendly and low cost cloud implementation for genome-wide association studies

Machine Learning Methodologies for Prediction of Rhythm-Control Strategy in Patients Diagnosed With Atrial Fibrillation: Observational, Retrospective, Case-Control Study. 

Implementation of Collection of Patients’ Disability Status by Centralized Scheduling.

Thirty-day outcomes of children and adolescents with COVID-19: an international experience.

Tissue tumor mutational burden (TMB) as a biomarker of efficacy with immune checkpoint inhibitors (ICI) in metastatic gastrointestinal (mGI) cancers.

Real-time electronic health record mortality prediction during the COVID-19 pandemic: a prospective cohort study.

Prediction of drug-induced long QT syndrome using machine learning applied to harmonized electronic health record data.

Characteristics and outcomes of over 300,000 patients with COVID-19 and history of cancer in the United States and Spain.

Cost and healthcare utilization analysis of culturally sensitive, shared medical appointment model for Latino children with type 1 diabetes.

Host methylation predicts SARS-CoV-2 infection and clinical outcome.

Student-run Clinic Effect on Emergency Department Utilization (SCEEDU): An Analysis of the DAWN Clinic Impact in Colorado.

 Opportunity for genotype‐guided prescribing among adult patients in 11 US health systems.

Comparison of immediate hypersensitivity reactions to preoperative antibiotics in patients labeled as penicillin allergic.

Choosing Between Mastectomy and Breast-Conserving Therapy: Is Patient Distress an Influencing Factor?. 

Associations between socioeconomic context and congenital heart disease related outcomes in adolescents and adults.

Unsupervised clinical relevancy ranking of structured medical records to retrieve condition-specific information in the emergency department.

The COVIDome explorer researcher portal.

The Impact of Race, Ethnicity and Insurance Status on Surgery Rates for Benign Prostatic Hyperplasia.

Assessing the utility and accuracy of ICD10‐CM non‐traumatic subarachnoid hemorrhage codes for intracranial aneurysm research.

Increased mortality associated with uncontrolled diabetes mellitus in patients with pulmonary cryptococcosis: A single US cohort study. 

Assessing prescriber behavior with a clinical decision support tool to prevent drug-induced long QT syndrome. 

Seroconversion stages COVID19 into distinct pathophysiological states.

Specialized interferon ligand action in COVID19.

Genome-wide association meta-analysis identifies novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation.

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